Quick Comparison
| Aloe Vera | EGF (Epidermal Growth Factor) | |
|---|---|---|
| Typical Concentration | Apply pure aloe vera gel or products containing high concentrations (>50% aloe). For sunburn: apply liberally and frequently. For daily use as a soothing moisturizer: apply after cleansing. Refrigerating aloe gel provides additional cooling relief. | Concentrations vary by product (typically measured in ppm or sh-oligopeptide-1 percentage). Applied once or twice daily. Best used after procedures or on aging skin. Apply before oils/occlusives. Store in refrigerator for stability. |
| Application | Topical (gel, cream, lotion). Pure inner leaf gel or standardized extracts. Apply to clean skin. | Topical (serum, cream, ampoule). Apply to clean skin. Temperature-sensitive — some products require refrigeration. |
| Research Papers | 10 papers | 10 papers |
| Categories |
Mechanism of Action
Aloe Vera
Acemannan (acetylated mannan polysaccharide) is the primary bioactive—it binds to macrophage mannose receptors and stimulates macrophage phagocytosis, cytokine release (IL-1, TNF-α), and fibroblast proliferation via growth factor induction, accelerating wound healing and granulation tissue formation. Acemannan also promotes keratinocyte proliferation and migration. Aloesin (a chromone) inhibits tyrosinase and tyrosinase-related protein-1 (TRP-1), providing mild brightening. Aloe-emodin has antibacterial activity against Gram-positive bacteria and antiviral effects. Salicylic acid naturally present in aloe inhibits cyclooxygenase (COX), providing mild anti-inflammatory and analgesic effects. The gel matrix forms a semi-occlusive film that reduces transepidermal water loss (TEWL). Aloe contains glucomannan, which acts as a humectant. Proteolytic enzymes (bradykinase) may contribute to anti-inflammatory activity. Use inner leaf gel to avoid anthraquinones in the latex that can cause irritation.
EGF (Epidermal Growth Factor)
EGF binds EGFR/ErbB1 on keratinocytes and fibroblasts, triggering dimerization and autophosphorylation. Activates MAPK/ERK (Ras-Raf-MEK-ERK) and PI3K/AKT pathways, promoting proliferation, migration (actin reorganization, focal adhesion turnover), and differentiation. Upregulates cyclin D1, inhibits p27. Stimulates fibroblast collagen types I/III and hyaluronic acid via HAS2. In wound healing, accelerates re-epithelialization via keratinocyte migration and reduces scarring via TGF-beta modulation. For anti-aging, promotes cellular renewal and extracellular matrix production. Theoretical cancer concern from EGFR's growth role — topical EGF has not been shown to penetrate to basal layer or systemic circulation significantly.
Risks & Safety
Aloe Vera
Common
May cause drying if used alone (aloe lacks occlusive properties, so moisture can evaporate).
Serious
None from topical use.
Rare
Allergic contact dermatitis (especially to compounds in the latex/outer leaf, not the inner gel). Oral aloe vera is a separate concern with laxative effects.
EGF (Epidermal Growth Factor)
Common
Very well-tolerated.
Serious
Theoretical concern about promoting growth of pre-existing skin cancers (unproven but debated).
Rare
Mild irritation.
Full Profiles
Aloe Vera →
One of the oldest and most recognized soothing ingredients, used for millennia for burns, wounds, and skin irritation. Aloe vera gel contains over 75 active compounds including polysaccharides, vitamins, minerals, and enzymes. It provides immediate cooling, hydration, and anti-inflammatory relief. The evidence is strongest for wound healing, sunburn recovery, and moisturization.
EGF (Epidermal Growth Factor) →
A signaling protein that stimulates cell growth, proliferation, and differentiation. In skincare, EGF promotes wound healing, skin renewal, and collagen production. Originally used in medical wound care and post-laser recovery, it has become popular in Korean skincare for anti-aging. It is one of the few growth factors with evidence for topical skincare efficacy.