Licorice Root ExtractvsSnail Mucin

Glabridin competitively inhibits tyrosinase by binding copper active site (CuA, CuB), blocking tyrosine to L-DOPA hydroxylation and DOPA to dopaquinone oxidation. Also inhibits tyrosinase-related protein 1 (TRP-1). Liquiritin disperses existing melanin via melanosome transfer inhibition and autophagy pathway upregulation in keratinocytes. Glycyrrhizin inhibits COX-2 and 5-lipoxygenase, reducing prostaglandin and leukotriene production. Multi-mechanism brightening: tyrosinase inhibition, melanin dispersal, anti-inflammation. Unlike hydroquinone, no melanocyte cytotoxicity — suitable for long-term use and all skin tones. Glabridin has free radical scavenging antioxidant activity. Glycyrrhizin's 11-beta-HSD inhibition has minimal systemic effect with topical use.

Snail secretion filtrate (Cryptomphalus aspersa) is a complex mixture of bioactive compounds. Hyaluronic acid (multiple molecular weights) provides humectant hydration by binding water in the stratum corneum and dermis. Glycoproteins and proteoglycans contain growth factors and enzymes that accelerate wound healing, promote fibroblast and keratinocyte proliferation, and support extracellular matrix remodeling. Copper peptides (e.g., GHK-Cu) naturally present stimulate collagen and elastin production via upregulation of collagen genes and inhibition of MMPs; they also have antioxidant and anti-inflammatory activity. Antimicrobial peptides (e.g., defensin-like molecules) provide mild protection against bacteria. Allantoin soothes, promotes cell turnover, and supports barrier repair. The secretion also contains glycolic acid (mild exfoliation), vitamins, and trace minerals. The combination replicates functions of multiple skincare ingredients—hydration, wound healing, antioxidant defense, and barrier support—in a single biocompatible secretion. Filtrate processing removes snail cells while preserving bioactive compounds.