Snail MucinvsWitch Hazel

Snail secretion filtrate (Cryptomphalus aspersa) is a complex mixture of bioactive compounds. Hyaluronic acid (multiple molecular weights) provides humectant hydration by binding water in the stratum corneum and dermis. Glycoproteins and proteoglycans contain growth factors and enzymes that accelerate wound healing, promote fibroblast and keratinocyte proliferation, and support extracellular matrix remodeling. Copper peptides (e.g., GHK-Cu) naturally present stimulate collagen and elastin production via upregulation of collagen genes and inhibition of MMPs; they also have antioxidant and anti-inflammatory activity. Antimicrobial peptides (e.g., defensin-like molecules) provide mild protection against bacteria. Allantoin soothes, promotes cell turnover, and supports barrier repair. The secretion also contains glycolic acid (mild exfoliation), vitamins, and trace minerals. The combination replicates functions of multiple skincare ingredients—hydration, wound healing, antioxidant defense, and barrier support—in a single biocompatible secretion. Filtrate processing removes snail cells while preserving bioactive compounds.

Hamamelitannin (a gallotannin) and polyphenols cross-link and precipitate stratum corneum proteins via hydrogen bonding and hydrophobic interactions, temporarily tightening skin surface, reducing pore appearance, creating matte finish by binding sebum. Tannins inhibit 5-lipoxygenase (reducing leukotriene B4) and scavenge reactive oxygen species. Gallic acid, catechins, proanthocyanidins provide antioxidant protection. Hamamelitannin inhibits elastase, potentially protecting elastin. Astringent effect temporary (hours) — does not alter pore size or sebum production long-term. Alcohol-free witch hazel (distillate or hydrosol) preserves benefits; alcohol formulations add drying and barrier-disrupting effects. Polyphenols may have mild vasoconstrictive effects, reducing erythema.