AllantoinvsHemp Seed Oil

Allantoin (5-ureidohydantoin) stimulates cell proliferation and tissue regeneration by promoting fibroblast activity, keratinocyte proliferation, and extracellular matrix synthesis including collagen and glycosaminoglycans. It acts as a mild keratolytic by promoting the natural desquamation process—loosening corneocyte adhesion and facilitating shedding—without the irritation, pH disruption, or barrier compromise associated with alpha- or beta-hydroxy acids. Allantoin has anti-inflammatory properties through modulation of prostaglandin synthesis (inhibiting COX-2 and reducing PGE2) and may downregulate pro-inflammatory cytokines. Its moisturizing effect comes from increasing the water-binding capacity of the extracellular matrix and stratum corneum; it is highly soluble and forms hydrogen bonds with water. Allantoin also promotes wound epithelialization. Its safety profile—non-irritating, non-sensitizing, non-comedogenic—makes it suitable for compromised skin, post-procedure care, and infant formulations.

Linoleic acid (55-60%) is key active — acne-prone skin has been shown to have 50% less in sebum compared to normal skin; deficiency may contribute to abnormal follicular keratinization and comedone formation. Topical supplementation normalizes sebum composition (linoleate is component of sebum triglycerides), reduces comedone formation, supports ceramide synthesis. GLA (gamma-linolenic acid, 2-4%) converts to DGLA, which inhibits pro-inflammatory leukotriene B4 synthesis (5-lipoxygenase competition) and is precursor to anti-inflammatory prostaglandin E1. 3:1 omega-6:omega-3 ratio considered optimal for skin. Natural vitamin E provides antioxidant protection. Comedogenic rating 0. Contains 0% THC/CBD. Ideal for acne-prone, inflamed, eczema-prone skin. Goes rancid within 3-6 months — store refrigerated.