Hemp Seed Oil
Cold-pressed from Cannabis sativa seeds, hemp seed oil has an ideal 3:1 ratio of omega-6 to omega-3 fatty acids — the ratio considered optimal for skin health. It is rich in linoleic acid (which acne-prone skin is deficient in), gamma-linolenic acid (GLA, a potent anti-inflammatory), and natural vitamin E. Does not contain THC or CBD. One of the best oils for acne-prone, inflamed, or eczema-prone skin.
Concentration & Usage
Apply 2-5 drops as a moisturizer or mix with other products. Cold-pressed, unrefined oil is dark green with a nutty scent. Suitable for oily and acne-prone skin. Comedogenic rating: 0 (non-comedogenic). Use within 3-6 months and store refrigerated.
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99%+ purity · third-party lab tested
Mechanism of Action
Linoleic acid (55-60%) is key active — acne-prone skin has been shown to have 50% less in sebum compared to normal skin; deficiency may contribute to abnormal follicular keratinization and comedone formation. Topical supplementation normalizes sebum composition (linoleate is component of sebum triglycerides), reduces comedone formation, supports ceramide synthesis. GLA (gamma-linolenic acid, 2-4%) converts to DGLA, which inhibits pro-inflammatory leukotriene B4 synthesis (5-lipoxygenase competition) and is precursor to anti-inflammatory prostaglandin E1. 3:1 omega-6:omega-3 ratio considered optimal for skin. Natural vitamin E provides antioxidant protection. Comedogenic rating 0. Contains 0% THC/CBD. Ideal for acne-prone, inflamed, eczema-prone skin. Goes rancid within 3-6 months — store refrigerated.
Regulatory Status
Cosmetic ingredient and food. Available OTC worldwide. Contains 0% THC/CBD.
Risks & Safety
Common
Can feel slightly heavy for very oily skin. Goes rancid quickly if not stored properly.
Serious
None.
Rare
Very rare allergic reaction.
Compare Hemp Seed Oil With
Research Papers
7Published: October 10, 2025
AI Summary
Hemp seed oil showed synergy with gentamicin (Fractional Inhibitory Concentration Index < 0.5), reducing the MIC of gentamicin-resistant S. pseudintermedius strains (≥16 µg/ml) below the clinical susceptibility breakpoint (≤4 µg/ml).
Published: September 17, 2022
AI Summary
Abstract too short to summarize.
Published: December 30, 2021
AI Summary
An increasing number of studies have investigated the adverse effect profile of oral cannabinoids; however, few studies have provided sufficient data on the tolerability of topical cannabinoids in human participants.
Published: October 30, 2025
AI Summary
The findings highlighted significant metabolic features, such as vitamin E, clionasterol, and linoleic acid, related with anti-aging properties via elastase inhibition. Molecular docking experiments aligned with biological results, showing strong binding affinities and enhanced inhibitory effects in all combinations.
Published: February 9, 2025
AI Summary
Knee osteoarthritis (OA) is one of the most common and debilitating diseases, especially in the elderly. Hemp seed oil is a plant product that has been used as a food or drug since ancient times because of its anti-inflammatory and analgesic properties.
Published: March 18, 2025
AI Summary
A growing number of publications are devoted to topical cannabinoid therapies in present-day cosmetology, as they appear to be safe and effective treatment modalities aimed at improving the comfort and quality of life of patients with atopic dermatitis (AD). A thorough patient interview, physical ex
Published: December 20, 2024
AI Summary
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease that severely impairs patient's life quality and represents significant therapeutic challenge due to its pathophysiology arising from skin barrier dysfunction.
Frequently Asked Questions
What is Hemp Seed Oil used for?
Cold-pressed from Cannabis sativa seeds, hemp seed oil has an ideal 3:1 ratio of omega-6 to omega-3 fatty acids — the ratio considered optimal for skin health. It is rich in linoleic acid (which acne-prone skin is deficient in), gamma-linolenic acid (GLA, a potent anti-inflammatory), and natural vitamin E. Does not contain THC or CBD. One of the best oils for acne-prone, inflamed, or eczema-prone skin.
What are the side effects of Hemp Seed Oil?
Common: Can feel slightly heavy for very oily skin. Goes rancid quickly if not stored properly. Serious: None. Rare: Very rare allergic reaction.
How is Hemp Seed Oil administered?
Hemp Seed Oil is administered via topical (pure oil). cold-pressed, unrefined. can also be taken orally as a supplement..
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